Originally Posted by Mermaid1962
Do you know that it has?
It seems likely that, if in vitro
was used with Kiko, then it was also tried- and -failed- with Masako.
No, of course I don't know it for a fact; however, I cannot imagine this chance would be overlooked.
Concern over lack of an heir has plagued the Imperial Family for quite some time (even before the birth of Princess Aiko).