The Queen will acknowledge the "bumpy" path the nation has taken over the past year in her Christmas Day message.
She will say the path is never "smooth" but "small steps" can heal divisions.
It comes after a year of intense political debate over Brexit, as well as a number of personal events affecting the Royal Family.
Last month, the Duke of York withdrew from public life after a BBC interview about his ties to sex offender Jeffrey Epstein, who killed himself in August.
Meanwhile in January, the Duke of Edinburgh was involved in a car crash while driving near the Queen's Sandringham estate in Norfolk. He escaped uninjured, but two women required hospital treatment.
Prince Philip, 98, is spending a fourth night in a London hospital after being admitted last Friday in relation to a "pre-existing condition".
In September, the Duke and Duchess of Sussex publicly revealed their struggles under the media spotlight during their tour of southern Africa.
Referring to the life of Jesus and the importance of reconciliation, the Queen, 93, said "small steps taken in faith and in hope can overcome long-held differences and deep-seated divisions to bring harmony and understanding."
"The path, of course, is not always smooth, and may at times this year have felt quite bumpy, but small steps can make a world of difference."
The broadcast was produced by the BBC and recorded in the green drawing room of Windsor Castle after the general election, but before Prince Philip was admitted to hospital.
The Queen wore a royal blue cashmere dress by Angela Kelly, and the sapphire and diamond Prince Albert brooch, a present from Albert to Queen Victoria on the eve of their wedding in 1840.
She is filmed sitting at a desk featuring photographs of her family, including one of the Prince of Wales and Duchess of Cornwall, and a black-and-white image of the Queen's father, King George VI.
There is also a photograph of of the Duke and Duchess of Cambridge and their children - Prince George, Princess Charlotte and Prince Louis - perched on and around a motorbike and sidecar - an image used for the couple's Christmas card.
Analysis: A coded message? (by Nicholas Witchell BBC Royal Correspondent)
It has been a year which, at times, may have felt "quite bumpy", so the Queen will say in her Christmas broadcast.
It is a choice of words which will inevitably prompt speculation about what it is that she's referring to.
She does not offer any clarification herself, though the remark is made in the context of overcoming what she calls "long-held differences" and how "small steps taken in faith and in hope can overcome deep-seated divisions".
The obvious interpretation is that this is the Queen's - as ever - coded message to the country to try to move on from the divisions of the Brexit debate, but the reference to a "bumpy" year may also be taken to refer to events within her own family after a year which has seen the Duke of Edinburgh's car accident, the Duke and Duchess of Sussex complaining about the difficulties of being in the public eye and the controversies around Prince Andrew.
The Queen will be hoping that for Christmas she will at least be reunited with her husband, and his family will be hoping he's well enough today to join them at Sandringham.