Toledo said:
Anyone knows if the gene has been removed from the current Royals we discuss in here?
[FONT="]Hemophilia is transmitted on the X chromosome and it is a recessive trait. Women have XX chromosomes and men have XY chromosomes. Each person gets 1 chromosome from each parent. A woman has XX chromosome so she can only pass an X chromosome onto her children. A man has XY and can pass either chromosome on so the father determines the child's sex. If the father passes the X, it's a girl and if the father passes the Y, it's a boy. Now let's look at a woman carrying hemophilia. The hemophilia gene will be on only 1 of her chromosomes so the carrier mother has a 50% chance of passing on the chromosome with hemophilia. If she passes the chromosome on to a daughter, that daughter will be a carrier. The daughter will not have hemophilia because she has a healthy X chromosome from her father. But if the mother passes that X chromosome on to a boy, he will be a hemophiliac. The only way for a female to be a hemophiliac is for her to be the daughter of a carrier and a hemophiliac. The daughter of a hemophiliac will always be a carrier because her father can only pass on an X chromosome with hemophilia on it. However a hemophiliac's sons will not have hemophilia because the hemophiliac father will pass on a Y chromosome and his wife will pass on a healthy X chromosome.
Victoria's youngest son Leopold was a hemophiliac. He had 2 children: a daughter Alice, who had to be a carrier and a son Charles who had to be unaffected as I just explained. Alice had a son and a daughter. The son was hemophiliac and died in a car accident at age 21 so his line stopped. It is possible Alice's daughter was a carrier but so far none of her descendants have hemophilia but that doesn't necessarily mean she was not a carrier.
Victoria's 2nd daughter Alice was a carrier. Alice married Grand Duke Louis of Hesse-Darmstadt. Their son Friedrich (Frittie) was hemophiliac. When Frittie was 3, he came running into Alice's room and was running so fast that he fell out the window. By evening he was dead due to the uncontrollable bleeding.
Alice's daughter Irene married Prince Henry of Prussia. They had 2 hemophiliac sons but no daughters. One of Irene's sons died at age 4. The other, Waldemar, actually survived for quite a while. Waldemar died at age 56 and he had married but had no children. So the hemophilia from Frittie and Irene died out.
Alice's youngest surviving daughter was Alix who married Nicholas II of Russia and became Alexandra Feodorovna. And as we know, their son Alexei was a hemophiliac. We do not know if any of their 5 daughters were carriers but it is probable. So hemophilia did not descend through this line since all the children were killed.
Victoria's youngest daughter Beatrice was also a carrier. Beatrice had 3 sons and 1 daughter. Her son Leopold was a sufferer but he died at age 23 with no children. Her son Maurice also died at age 23 with no children...he MAY have had hemophilia. So there is no hemophilia descent through Beatrice's sons. Her daughter Victoria Eugenie known as Ena was a carrier and brought hemophilia into the Spanish Royal Family. Ena married King Alfonso XIII of Spain and they are the grandparents of King Juan Carlos of Spain...but there is no hemophilia in that line. Three of Ena's sons had hemophilia...one was stillborn. Her son Alfonso had it but he died in a car accident at age 31. He married but had no children. Her son Gonzalo also had it and he died in a car accident at age 20. So there is no hemophilia descent through any of Ena's sons. Now Ena had a daughter Beatriz and she is a possible carrier but none of her descendants have hemophilia. If it still exists, it is in the descendants of Beatriz, who was King Juan Carlos's aunt or in the descendants of Alice, the daughter of Prince Leopold. All the other lines have died out.[/FONT]
