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#41
09-10-2006, 05:45 AM
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There is also the possibility that Princess Louise, Duchess of Argyll was a carrier. However she had no children.
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60th Birthday of HRH Charles, The Prince of Wales on November 14th 2008 Everything I write here is my opinion and I mean no offence by it. 
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#42
09-10-2006, 09:43 AM
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#43
09-10-2006, 07:23 PM
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I posted this before but I will post it again. What follows is how hemophilia is transmitted. Hemophilia is transmitted on the X chromosome and it is a recessive trait. Women have XX chromosomes and men have XY chromosomes. Each person gets 1 chromosome from each parent. A woman has XX chromosome so she can only pass an X chromosome onto her children. A man has XY and can pass either chromosome on so the father determines the child's sex. If the father passes the X, it's a girl and if the father passes the Y, it's a boy. Now let's look at a woman carrying hemophilia. The hemophilia gene will be on only 1 of her chromosomes so the carrier mother has a 50% chance of passing on the chromosome with hemophilia. If she passes the chromosome on to a daughter, that daughter will be a carrier. The daughter will not have hemophilia because she has a healthy X chromosome from her father. But if the mother passes that X chromosome on to a boy, he will be a hemophiliac. The only way for a female to be a hemophiliac is for her to be the daughter of a carrier and a hemophiliac. The daughter of a hemophiliac will always be a carrier because her father can only pass on an X chromosome with hemophilia on it. However a hemophiliac's sons will not have hemophilia because the hemophiliac father will pass on a Y chromosome and his wife will pass on a healthy X chromosome.
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Susan "You are a pest, by the very nature of that camera in your hand." Princess Anne to a photographer
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#45
09-15-2006, 05:44 AM
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'To dare is to lose one step for but a moment, not to dare is to lose oneself forever' - Crown Prince Frederick of Denmark in a letter to Miss Mary Donaldson as stated by them on their official engagement interview.
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#46
09-15-2006, 06:06 AM
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I read that in medieval times haemophilia was so common among Europe's nobles that it was called the "malaise des rois" or disease of kings. As Queen Victoria's ancestors from her mother's side were mostly from Central European nobility and the disease can lie low for several generations one can imagine that it did not start with her but she inherited it. Maybe the close relation to her husband from this side of the family "awoke" the disease as I found in a report that this can happen.
Has anyone followed the family tree of the other daughter of Victoria of Saxe-Coburg & Gotha, born princess of Leiningen? her daughter married a prince of Hohenlohe-Langenburg and had a daughter who married a duke of Schleswig-Holstein-Sonderburg-Augustenburg. And two of her three sons died within the first two years after their birth. You can find the dates here: http://www.thepeerage.com/p10368.htm#i103673 under Adelheid princess of Hohenlohe-Langenburg. The interesting thing is that Adelheid's daughter Auguste Viktoria became Wilhelm II.'s empress, the emperor being a grandson of queen Victoria... Were there haemophiliacs in this branch of the Prussian Royal family? Following the family tree in the female line you end up with princess Sophia of Greece, today the queen of Spain and then her daughters... Well, they seem to be healty enough... Another Royal with these genes in the female line is Sybilla of Saxe, Crown princess of Sweden, mother of king Carl XVI. Gustaf... This branch seems to be healthy as well.
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'To dare is to lose one step for but a moment, not to dare is to lose oneself forever' - Crown Prince Frederick of Denmark in a letter to Miss Mary Donaldson as stated by them on their official engagement interview. Last edited by Jo of Palatine; 09-15-2006 at 06:30 AM.
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#47
09-15-2006, 12:24 PM
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Last edited by Furienna; 09-15-2006 at 12:26 PM.
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#48
09-15-2006, 07:35 PM
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The only hemophilia in the Prussian royal family were the two sons of Prince Henry, son of Victoria, Princess Royal, and Princess Irene of Hesse-Darmstadt, daughter of Princess Alice. The hemophilia gene came from Princess Alice, daughter of Queen Victoria. As I have explained before, Albert's close relation to Victoria had nothing to do with the hemophilia in the family. If Albert had the hemophilia gene, he would have been a hemophiliac. See my previous post in this thread posted on 9/10/06 for an explanation.
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Susan "You are a pest, by the very nature of that camera in your hand." Princess Anne to a photographer Last edited by SusanE; 09-16-2006 at 06:21 PM.
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#49
09-17-2006, 09:17 AM
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http://de.wikipedia.org/wiki/H%C3%A4mophilie http://www.werlhof-institut.de/Patie...en/content.htm http://ärzte-aktuell.de/index.php/Bluter and other medical pages in German. Just google Haemophilie or "Bluterkrankheit" and "Krankheit der Könige" and you'll find the links.
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'To dare is to lose one step for but a moment, not to dare is to lose oneself forever' - Crown Prince Frederick of Denmark in a letter to Miss Mary Donaldson as stated by them on their official engagement interview.
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#50
09-17-2006, 06:53 PM
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I've read a lot about hemophilia and about the middle ages and never read about hemophilia being prevalent in noble families then. It wasn't even named "hemophilia" until 1828. Jewish texts of the second century AD mention the exemption of male boys from circumcision if two previous brother had died of bleeding after the procedure. The first modern description of hemophilia is attributed to Dr. John Conrad Otto, a doctor in Philadelphia, who in 1803 published a treatise entitled "An account of an haemorrhagic disposition existing in certain families." The genetics of the disease were not understood until the 20th century.
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Susan "You are a pest, by the very nature of that camera in your hand." Princess Anne to a photographer
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#51
09-17-2006, 07:32 PM
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Well, I watched a documentary once, and it was about how a disease, that was carried down through generations of English monarchs. It was, for example, the very disease, that George III suffered from in the end of his life. But I don't think it was haemophilia. Was it called porphyria?
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#52
09-17-2006, 08:13 PM
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Porphyria is a metabolic disease with many symptoms and most sufferers do not exhibit the severe behavioral symptoms that George III exhibited. If you have seen the file "The Madness of King George," you will be aware of the symptoms. Modern medicine provides treatment for porphyria that was not available to George III. See http://health.allrefer.com/health/po...treatment.html Porphyria is "a group of inherited disorders involving abnormalities in the production of heme pigments (the base material responsible for hemoglobin (red blood cell pigment), myoglobin (reddish muscle cell pigment) and another group of materials called cytochromes." (From http://health.allrefer.com/health/porphyria-info.html#definition) From http://health.allrefer.com/health/po...-symptoms.html Porphyria symptoms and signs include: Red urine (sometimes called purple) Sensitivity to sunlight Blister formation on exposure to sunlight Skin swelling on exposure to sunlight Photodermatitis Crampy abdominal pain (may be severe) Constipation Vomiting Pain in the limbs Personality change Numbness or tingling Muscle pain Muscle weakness or paralysis Prince William of Gloucester, who died in a plane crash in 1972, was diagnosed with porphyria. He was the eldest son of Prince Henry, Duke of Gloucester (son of George V). I do not know the type or extent of his symptoms. According to http://www.sussex.ac.uk/press_office.../article1.html , "There is a one-in-two chance of any member of the Royal family with the faulty gene passing it on to each offspring. Of that number, around 10% will suffer symptoms."
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Susan "You are a pest, by the very nature of that camera in your hand." Princess Anne to a photographer Last edited by SusanE; 09-17-2006 at 08:19 PM.
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#53
09-24-2006, 02:02 PM
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Has it absolutely been publicly acknowledged that Haemophilia doesn't exist in these royal families? I would love to know the source. Will we really know if not? The reason I ask is that there are plenty of blood clotting medications in existance today that weren't around when royal members were dying off. So the dangers of this illness are as risky as they back then. Someone educate me please if these answers are known. Thanks.
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#55
09-24-2006, 04:37 PM
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Queen Victoria's youngest son Leopold was a hemophiliac. He had 2 children: a daughter Alice, who had to be a carrier and a son Charles who had to be unaffected as I have explained in previous posts. Alice had a son and a daughter. The son was hemophiliac and died in a car accident at age 21 so his line stopped. It is possible Alice's daughter was a carrier but so far none of her descendants have hemophilia but that doesn't necessarily mean she was not a carrier. Queen Victoria's 2nd daughter Alice was a carrier. Alice married Grand Duke Louis of Hesse-Darmstadt. Their son Friedrich (Frittie) was hemophiliac. When Frittie was 3, he came running into Alice's room and was running so fast that he fell out the window. By evening he was dead due to the uncontrollable bleeding. Alice's daughter Irene married Prince Henry of Prussia. They had 2 hemophiliac sons but no daughters. One of Irene's sons died at age 4. The other, Waldemar, actually survived for quite a while. Waldemar died at age 56 and he had married but had no children. So the hemophilia from Frittie and Irene died out. Alice's youngest surviving daughter was Alix who married Nicholas II of Russia and became Alexandra Feodorovna. And as we know, their son Alexei was a hemophiliac. We do not know if any of their 5 daughters were carriers but it is probable. So hemophilia did not descend through this line since all the children were killed. Victoria's youngest daughter Beatrice was also a carrier. Beatrice had 3 sons and 1 daughter. Her son Leopold was a sufferer but he died at age 23 with no children. Her son Maurice also died at age 23 with no children...he MAY have had hemophilia. So there is no hemophilia descent through Beatrice's sons. Her daughter Victoria Eugenie known as Ena was a carrier and brought hemophilia into the Spanish Royal Family. Ena married King Alfonso XIII of Spain and they are the grandparents of King Juan Carlos of Spain...but there is no hemophilia in that line. Three of Ena's sons had hemophilia...one was stillborn. Her son Alfonso had it but he died in a car accident at age 31. He married but had no children. Her son Gonzalo also had it and he died in a car accident at age 20. So there is no hemophilia descent through any of Ena's sons. Now Ena had a daughter Beatriz and she is a possible carrier but none of her descendants have hemophilia. If it still exists, it is in the descendants of Beatriz, who was King Juan Carlos's aunt or in the descendants of Alice, the daughter of Prince Leopold. All the other lines have died out.
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Susan "You are a pest, by the very nature of that camera in your hand." Princess Anne to a photographer
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#56
09-24-2006, 06:07 PM
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I appreciate all of the replies especially SusanE's complete breakdown. Maybe we just won't ever know about Beatriz or Alice's lines. Thanks again.
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#57
02-01-2007, 02:01 PM
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I think that all of the European Royal famalies may have been quietly researching this topic on their own now for years. It seems to me that recently some sort of conformation may have been made to these famalies in regards to the genetic downfalls of intermarrying. Just look at all of the royal famalies bringing in new blood! I don't think that this is coincidence.
Let's see..... Hakon & MM Fredrick & Mary Wilehm & Maxima Felipe & letizia Victoria of Sweden & Daniel (probably to marry) William & Kate (most likely to marry but you never know) Even the Japanese RF Narhuito & Masako Royal brothers & sisters of heir apparents are marrying new blood now whereas before this was unthinkable. The media seems to try to spin this as Royals marrying for love which may be true (Royals trying to avoid the whole Diana & Charles thing) which makes a very romantic and great story but there seems to be more to this than meets the eye. Even the some of the older Royal generations did not marry royal (King of Sweden) which is definately a good thing!! Could you imagine the genetic disorders/diseases that may have occured if he had - seeing as how it's possible he passed down dyslexia to his present children had he intermarryed imagine what the health ramifications could have been to those children. Same with Norway, maybe there were illness' that the public was not aware of that tipped off the Royals to hunt for new blood. I thought this article was very good. Thank you for posting. bulletin: The University of Sussex Newsletter The Royal Family's Toxic Time-Bomb Friday 25th June 1999 Last edited by lashinka2002; 02-01-2007 at 02:09 PM.
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