1241- death of Isabella of England, Holy Roman Empress. Daughter of King John, she married Frederick II, Holy Roman Emperor. She was his third wife. Of her four children only the youngest Margaret would reach adulthood (one son reached 15, 2 children died in infancy). Margaret married Albert 'the degenerate' Landgrave of Thuringia (heir to the Margrave of Meissen). Margaret famously left her husband after discovering his affair but not before biting her son on the cheek (He became known as Frederick 'the bitten' after. The family had some interesting monichers in Meissen). Margaret fled her husband to Frankfurt where she was aided by the citizens, but died six weeks later.